Drug interactions
Isoniazid + Vinblastine
Severity: Moderate
Isoniazid and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may reduce CYP3A4 metabolism of vinblastine, which could increase its myelosuppressive and neurotoxic effects. Both drugs can also cause peripheral neuropathy, so additive neurotoxicity is a further concern.
What this interaction means in plain words
Isoniazid and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Vinblastine belongs to Oncology.
Why it happens
Possible CYP3A4 inhibition by isoniazid plus additive neurotoxicity.
What to do
Monitor blood counts and neurological status closely, and give pyridoxine alongside isoniazid as is standard practice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Vinblastine
Frequently asked questions
Can I take Isoniazid with Vinblastine?
MediHelp rates the interaction as moderate. Isoniazid and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may reduce CYP3A4 metabolism of vinblastine, which could increase its myelosuppressive and neurotoxic effects. Both drugs can also cause peripheral neuropathy, so additive neurotoxicity is a further concern.
How serious is the interaction between Isoniazid and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological status closely, and give pyridoxine alongside isoniazid as is standard practice.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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