Drug interactions
Isoniazid + Voclosporin
Severity: Moderate
Isoniazid and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a sensitive CYP3A4 substrate, and isoniazid has been reported to inhibit CYP3A4 to a modest degree. Higher voclosporin exposure could increase nephrotoxicity, hyperkalemia, hypertension and over-immunosuppression. The contraindication in labeling applies to strong CYP3A4 inhibitors, and isoniazid is a weak inhibitor, so the legacy severity looks overstated.
What this interaction means in plain words
Isoniazid and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Isoniazid weakly inhibits CYP3A4, reducing the metabolism of voclosporin.
What to do
Monitor eGFR, potassium and blood pressure when starting or stopping isoniazid, and reduce the voclosporin dose per labeling if renal function or tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Isoniazid with Voclosporin?
MediHelp rates the interaction as moderate. Isoniazid and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a sensitive CYP3A4 substrate, and isoniazid has been reported to inhibit CYP3A4 to a modest degree. Higher voclosporin exposure could increase nephrotoxicity, hyperkalemia, hypertension and over-immunosuppression. The contraindication in labeling applies to strong CYP3A4 inhibitors, and isoniazid is a weak inhibitor, so the legacy severity looks overstated.
How serious is the interaction between Isoniazid and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, potassium and blood pressure when starting or stopping isoniazid, and reduce the voclosporin dose per labeling if renal function or tolerability worsens.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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