Drug interactions
Isoniazid + Ziprasidone
Severity: Minor
Isoniazid and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may weakly inhibit CYP3A4, which contributes to ziprasidone clearance, so exposure could rise slightly. Because ziprasidone prolongs the QT interval, any increase is of some interest, but the effect is likely small.
What this interaction means in plain words
Isoniazid and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by isoniazid may modestly reduce ziprasidone metabolism.
What to do
Consider a baseline ECG and correct potassium and magnesium in patients with QT risk factors. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Isoniazid with Ziprasidone?
MediHelp rates the interaction as minor. Isoniazid and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may weakly inhibit CYP3A4, which contributes to ziprasidone clearance, so exposure could rise slightly. Because ziprasidone prolongs the QT interval, any increase is of some interest, but the effect is likely small.
How serious is the interaction between Isoniazid and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and correct potassium and magnesium in patients with QT risk factors. No routine dose change is needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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