Drug interactions
Isoproterenol + Metaproterenol
Severity: Moderate
Isoproterenol and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-adrenergic agonists, so giving them together adds to tachycardia, palpitations, tremor and arrhythmia risk. Beta-agonists also shift potassium into cells, so hypokalemia may be additive.
What this interaction means in plain words
Isoproterenol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor stimulation in the heart and skeletal muscle, including beta-2 mediated intracellular potassium shift.
What to do
Avoid concurrent use of multiple beta-agonists where possible. If unavoidable, monitor heart rate, ECG and serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Metaproterenol?
MediHelp rates the interaction as moderate. Isoproterenol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-adrenergic agonists, so giving them together adds to tachycardia, palpitations, tremor and arrhythmia risk. Beta-agonists also shift potassium into cells, so hypokalemia may be additive.
How serious is the interaction between Isoproterenol and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of multiple beta-agonists where possible. If unavoidable, monitor heart rate, ECG and serum potassium.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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