Drug interactions
Isoproterenol + Methylergonovine
Severity: Moderate
Isoproterenol and Methylergonovine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a vasoconstrictor that can raise blood pressure, while isoproterenol causes vasodilation and tachycardia. The effects partly oppose one another, but combined cardiovascular stress may be harmful and the evidence is limited.
What this interaction means in plain words
Isoproterenol and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing vasoactive effects with additive cardiac stress; no established synergistic mechanism.
What to do
Monitor blood pressure, heart rate and ECG, and watch for signs of ischemia when both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Methylergonovine?
MediHelp rates the interaction as moderate. Isoproterenol and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylergonovine is a vasoconstrictor that can raise blood pressure, while isoproterenol causes vasodilation and tachycardia. The effects partly oppose one another, but combined cardiovascular stress may be harmful and the evidence is limited.
How serious is the interaction between Isoproterenol and Methylergonovine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and watch for signs of ischemia when both are used.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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