Drug interactions
Isoproterenol + Olanzapine
Severity: Minor
Isoproterenol and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has beta-adrenergic-independent vasodilating effects and can cause tachycardia and orthostatic hypotension, while isoproterenol also causes vasodilation and tachycardia. The combination could add to hypotension and heart rate effects, but there is little clinical documentation.
What this interaction means in plain words
Isoproterenol and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoproterenol belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Possible additive hypotensive and tachycardic effects via alpha-1 blockade by olanzapine and beta-agonism by isoproterenol; not well established.
What to do
Monitor blood pressure and heart rate when isoproterenol is given to a patient taking olanzapine. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Olanzapine?
MediHelp rates the interaction as minor. Isoproterenol and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine has beta-adrenergic-independent vasodilating effects and can cause tachycardia and orthostatic hypotension, while isoproterenol also causes vasodilation and tachycardia. The combination could add to hypotension and heart rate effects, but there is little clinical documentation.
How serious is the interaction between Isoproterenol and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when isoproterenol is given to a patient taking olanzapine. No routine dose change is needed.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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