Drug interactions
Isoproterenol + Selegiline transdermal
Severity: Major
Isoproterenol and Selegiline transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline at antidepressant doses has MAO-inhibiting activity that can potentiate sympathomimetic amines. Isoproterenol is a direct beta agonist and is a weak substrate of MAO, so the effect is mainly additive cardiovascular stimulation, with tachycardia and blood pressure changes. The labeling for the patch advises against sympathomimetic use.
What this interaction means in plain words
Isoproterenol and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition and additive adrenergic stimulation may increase cardiovascular effects of the sympathomimetic.
What to do
Avoid unless essential; if isoproterenol is required, titrate at low doses with continuous ECG and blood pressure monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Selegiline transdermal?
MediHelp rates the interaction as major. Isoproterenol and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline at antidepressant doses has MAO-inhibiting activity that can potentiate sympathomimetic amines. Isoproterenol is a direct beta agonist and is a weak substrate of MAO, so the effect is mainly additive cardiovascular stimulation, with tachycardia and blood pressure changes. The labeling for the patch advises against sympathomimetic use.
How serious is the interaction between Isoproterenol and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless essential; if isoproterenol is required, titrate at low doses with continuous ECG and blood pressure monitoring.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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