Drug interactions
Isoproterenol + Yohimbe
Severity: Moderate
Isoproterenol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine in yohimbe is an alpha-2 antagonist that increases noradrenergic outflow, raising heart rate and blood pressure. Combined with isoproterenol, cardiac stimulation may be increased, leading to tachycardia, palpitations or arrhythmia.
What this interaction means in plain words
Isoproterenol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathetic stimulation from alpha-2 blockade and direct beta-adrenergic agonism.
What to do
Avoid yohimbe products in patients receiving isoproterenol, and monitor heart rate, rhythm and blood pressure if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Yohimbe?
MediHelp rates the interaction as moderate. Isoproterenol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine in yohimbe is an alpha-2 antagonist that increases noradrenergic outflow, raising heart rate and blood pressure. Combined with isoproterenol, cardiac stimulation may be increased, leading to tachycardia, palpitations or arrhythmia.
How serious is the interaction between Isoproterenol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe products in patients receiving isoproterenol, and monitor heart rate, rhythm and blood pressure if exposure occurs.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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