Drug interactions
Isoproterenol + Yohimbine
Severity: Moderate
Isoproterenol and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine, an alpha-2 antagonist, increases noradrenergic outflow and can raise blood pressure and heart rate. With isoproterenol, additive cardiovascular stimulation may cause tachycardia, palpitations and arrhythmias.
What this interaction means in plain words
Isoproterenol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathetic stimulation: direct beta-agonism plus enhanced norepinephrine release through alpha-2 blockade.
What to do
Monitor heart rate, rhythm and blood pressure, and avoid the combination in patients with arrhythmia or coronary disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Yohimbine?
MediHelp rates the interaction as moderate. Isoproterenol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine, an alpha-2 antagonist, increases noradrenergic outflow and can raise blood pressure and heart rate. With isoproterenol, additive cardiovascular stimulation may cause tachycardia, palpitations and arrhythmias.
How serious is the interaction between Isoproterenol and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and avoid the combination in patients with arrhythmia or coronary disease.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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