Drug interactions
Isosorbide dinitrate + Istradefylline
Severity: Minor
Isosorbide dinitrate and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day istradefylline can raise exposure to CYP3A4 substrates. Isosorbide dinitrate depends little on CYP3A4, so the effect is probably small.
What this interaction means in plain words
Isosorbide dinitrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide dinitrate belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline at higher doses.
What to do
No routine dose change. Monitor blood pressure and nitrate adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Isosorbide dinitrate with Istradefylline?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg/day istradefylline can raise exposure to CYP3A4 substrates. Isosorbide dinitrate depends little on CYP3A4, so the effect is probably small.
How serious is the interaction between Isosorbide dinitrate and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change. Monitor blood pressure and nitrate adverse effects.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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