Drug interactions
Isosorbide dinitrate + Larotrectinib
Severity: Minor
Isosorbide dinitrate and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro. Isosorbide dinitrate is cleared mainly by other routes, so any change in its exposure is unlikely to matter clinically.
What this interaction means in plain words
Isosorbide dinitrate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide dinitrate belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4, a minor route for isosorbide dinitrate.
What to do
No dose adjustment is needed. Routine blood pressure monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Isosorbide dinitrate with Larotrectinib?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro. Isosorbide dinitrate is cleared mainly by other routes, so any change in its exposure is unlikely to matter clinically.
How serious is the interaction between Isosorbide dinitrate and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine blood pressure monitoring is sufficient.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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