Drug interactions
Isosorbide dinitrate + Lofexidine
Severity: Moderate
Isosorbide dinitrate and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isosorbide dinitrate vasodilates, and lofexidine lowers blood pressure and heart rate. Together they may cause symptomatic hypotension, dizziness and syncope.
What this interaction means in plain words
Isosorbide dinitrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isosorbide dinitrate belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from nitrate vasodilation and central alpha-2 agonism.
What to do
Monitor blood pressure and pulse during initiation and dose changes, and counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Isosorbide dinitrate with Lofexidine?
MediHelp rates the interaction as moderate. Isosorbide dinitrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isosorbide dinitrate vasodilates, and lofexidine lowers blood pressure and heart rate. Together they may cause symptomatic hypotension, dizziness and syncope.
How serious is the interaction between Isosorbide dinitrate and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during initiation and dose changes, and counsel patients about orthostatic symptoms.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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