Drug interactions
Isosorbide mononitrate + Istradefylline
Severity: Minor
Isosorbide mononitrate and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline can raise exposure to CYP3A4 substrates. Isosorbide mononitrate is not primarily CYP3A4 cleared, so the effect is likely small, but nitrate effects such as headache and hypotension could be enhanced.
What this interaction means in plain words
Isosorbide mononitrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide mononitrate belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at 40 mg/day weakly inhibits CYP3A4, which could modestly raise levels of CYP3A4 substrates.
What to do
No routine dose change is needed. Monitor blood pressure and nitrate adverse effects if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Isosorbide mononitrate with Istradefylline?
MediHelp rates the interaction as minor. Isosorbide mononitrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline can raise exposure to CYP3A4 substrates. Isosorbide mononitrate is not primarily CYP3A4 cleared, so the effect is likely small, but nitrate effects such as headache and hypotension could be enhanced.
How serious is the interaction between Isosorbide mononitrate and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and nitrate adverse effects if istradefylline 40 mg/day is used.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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