Drug interactions
Isosorbide mononitrate + Lofexidine
Severity: Moderate
Isosorbide mononitrate and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isosorbide mononitrate vasodilates, and lofexidine lowers blood pressure and heart rate. Together they may cause symptomatic hypotension, dizziness and syncope.
What this interaction means in plain words
Isosorbide mononitrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isosorbide mononitrate belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from nitrate vasodilation and central alpha-2 agonism.
What to do
Monitor blood pressure and pulse during initiation and dose changes, and counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Isosorbide mononitrate with Lofexidine?
MediHelp rates the interaction as moderate. Isosorbide mononitrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isosorbide mononitrate vasodilates, and lofexidine lowers blood pressure and heart rate. Together they may cause symptomatic hypotension, dizziness and syncope.
How serious is the interaction between Isosorbide mononitrate and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during initiation and dose changes, and counsel patients about orthostatic symptoms.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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