Drug interactions
Isosorbide mononitrate + Tetracaine
Severity: Moderate
Isosorbide mononitrate and Tetracaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both nitrates and tetracaine have been associated with methemoglobinemia. Combined exposure may raise the risk, especially with large-area or mucosal tetracaine application, in infants, or in patients with G6PD deficiency.
What this interaction means in plain words
Isosorbide mononitrate and Tetracaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isosorbide mononitrate belongs to Cardiovascular; Tetracaine belongs to Central Nervous System.
Why it happens
Additive oxidation of hemoglobin to methemoglobin.
What to do
Monitor for cyanosis, dyspnea and low oxygen saturation unresponsive to oxygen, and measure methemoglobin if suspected. Limit the tetracaine dose and treat with methylene blue if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Other interactions of Tetracaine
- Chloroquine + Tetracaine Moderate
- Dapsone + Tetracaine Moderate
- Isosorbide dinitrate + Tetracaine Moderate
- Nitrofurantoin + Tetracaine Moderate
- Nitroglycerin + Tetracaine Moderate
- Paracetamol + Tetracaine Moderate
Frequently asked questions
Can I take Isosorbide mononitrate with Tetracaine?
MediHelp rates the interaction as moderate. Isosorbide mononitrate and Tetracaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both nitrates and tetracaine have been associated with methemoglobinemia. Combined exposure may raise the risk, especially with large-area or mucosal tetracaine application, in infants, or in patients with G6PD deficiency.
How serious is the interaction between Isosorbide mononitrate and Tetracaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cyanosis, dyspnea and low oxygen saturation unresponsive to oxygen, and measure methemoglobin if suspected. Limit the tetracaine dose and treat with methylene blue if toxicity occurs.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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