Drug interactions
Dapsone + Tetracaine
Severity: Moderate
Dapsone and Tetracaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both dapsone and local anesthetics such as tetracaine can cause methemoglobinemia, and the effects may be additive. Risk is higher with mucosal application, large doses or G6PD deficiency.
What this interaction means in plain words
Dapsone and Tetracaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Tetracaine belongs to Central Nervous System.
Why it happens
Additive oxidant-induced formation of methemoglobin.
What to do
Use the lowest effective dose of tetracaine and monitor for cyanosis, dyspnea and low pulse oximetry readings. Treat with methylene blue if symptomatic, unless G6PD deficient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Tetracaine
- Chloroquine + Tetracaine Moderate
- Isosorbide dinitrate + Tetracaine Moderate
- Isosorbide mononitrate + Tetracaine Moderate
- Nitrofurantoin + Tetracaine Moderate
- Nitroglycerin + Tetracaine Moderate
- Paracetamol + Tetracaine Moderate
Frequently asked questions
Can I take Dapsone with Tetracaine?
MediHelp rates the interaction as moderate. Dapsone and Tetracaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both dapsone and local anesthetics such as tetracaine can cause methemoglobinemia, and the effects may be additive. Risk is higher with mucosal application, large doses or G6PD deficiency.
How serious is the interaction between Dapsone and Tetracaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of tetracaine and monitor for cyanosis, dyspnea and low pulse oximetry readings. Treat with methylene blue if symptomatic, unless G6PD deficient.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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