Drug interactions
Isradipine + Mifepristone
Severity: Moderate
Isradipine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise isradipine concentrations, leading to hypotension, edema and tachycardia. Both drugs may also affect cardiac repolarization.
What this interaction means in plain words
Isradipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of isradipine.
What to do
Monitor blood pressure and heart rate and reduce the isradipine dose if hypotension or edema occurs. Consider an alternative antihypertensive that is less CYP3A4-dependent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Isradipine with Mifepristone?
MediHelp rates the interaction as moderate. Isradipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise isradipine concentrations, leading to hypotension, edema and tachycardia. Both drugs may also affect cardiac repolarization.
How serious is the interaction between Isradipine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the isradipine dose if hypotension or edema occurs. Consider an alternative antihypertensive that is less CYP3A4-dependent.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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