Drug interactions
Istradefylline + Ketoconazole
Severity: Moderate
Istradefylline and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases istradefylline exposure, which may worsen dyskinesia, dizziness and other adverse effects.
What this interaction means in plain words
Istradefylline and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases istradefylline metabolism.
What to do
Limit istradefylline to 20 mg once daily and monitor for dyskinesia and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Ketoconazole?
MediHelp rates the interaction as moderate. Istradefylline and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases istradefylline exposure, which may worsen dyskinesia, dizziness and other adverse effects.
How serious is the interaction between Istradefylline and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit istradefylline to 20 mg once daily and monitor for dyskinesia and other adverse effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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