Drug interactions
Istradefylline + Lorlatinib
Severity: Moderate
Istradefylline and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a CYP3A4 inducer and can lower istradefylline exposure. Reduced levels may lessen control of motor fluctuations in Parkinson's disease.
What this interaction means in plain words
Istradefylline and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by lorlatinib increases istradefylline metabolism.
What to do
Monitor motor symptoms; labeling advises avoiding strong CYP3A4 inducers with istradefylline, so consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Lorlatinib?
MediHelp rates the interaction as moderate. Istradefylline and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a CYP3A4 inducer and can lower istradefylline exposure. Reduced levels may lessen control of motor fluctuations in Parkinson's disease.
How serious is the interaction between Istradefylline and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms; labeling advises avoiding strong CYP3A4 inducers with istradefylline, so consider alternatives.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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