Drug interactions
Istradefylline + Morphine
Severity: Minor
Istradefylline and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline inhibits P-glycoprotein at higher doses and may increase exposure to P-gp substrates such as morphine. This could enhance opioid effects including sedation and respiratory depression, though the clinical impact is likely modest.
What this interaction means in plain words
Istradefylline and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Inhibition of P-glycoprotein efflux may increase morphine absorption and central penetration.
What to do
Monitor for excess sedation or respiratory depression when istradefylline is added, and reduce the morphine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Morphine?
MediHelp rates the interaction as minor. Istradefylline and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline inhibits P-glycoprotein at higher doses and may increase exposure to P-gp substrates such as morphine. This could enhance opioid effects including sedation and respiratory depression, though the clinical impact is likely modest.
How serious is the interaction between Istradefylline and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or respiratory depression when istradefylline is added, and reduce the morphine dose if these occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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