Drug interactions
Istradefylline + Nifedipine
Severity: Moderate
Istradefylline and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg daily dose istradefylline weakly inhibits CYP3A4 and can raise exposure to sensitive substrates such as nifedipine. This may increase hypotension and edema.
What this interaction means in plain words
Istradefylline and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing nifedipine clearance.
What to do
Monitor blood pressure and consider reducing the nifedipine dose if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nifedipine?
MediHelp rates the interaction as moderate. Istradefylline and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At the 40 mg daily dose istradefylline weakly inhibits CYP3A4 and can raise exposure to sensitive substrates such as nifedipine. This may increase hypotension and edema.
How serious is the interaction between Istradefylline and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider reducing the nifedipine dose if istradefylline 40 mg daily is used.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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