Drug interactions
Istradefylline + Nilotinib
Severity: Moderate
Istradefylline and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise nilotinib exposure. This increases the risk of QT prolongation and other dose-related effects.
What this interaction means in plain words
Istradefylline and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Istradefylline inhibits CYP3A4 and P-glycoprotein, decreasing nilotinib clearance.
What to do
Keep istradefylline at 20 mg daily where possible and monitor the QTc and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nilotinib?
MediHelp rates the interaction as moderate. Istradefylline and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise nilotinib exposure. This increases the risk of QT prolongation and other dose-related effects.
How serious is the interaction between Istradefylline and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily where possible and monitor the QTc and electrolytes.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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