Drug interactions
Istradefylline + Pazopanib
Severity: Moderate
Istradefylline and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses increases exposure to CYP3A4 and P-gp substrates, which may raise pazopanib concentrations. The effect was not seen at the lower 20 mg daily dose.
What this interaction means in plain words
Istradefylline and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Dose-dependent weak CYP3A4 and P-gp inhibition by istradefylline.
What to do
Keep istradefylline at 20 mg daily if possible and monitor for pazopanib toxicity including liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Pazopanib?
MediHelp rates the interaction as moderate. Istradefylline and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses increases exposure to CYP3A4 and P-gp substrates, which may raise pazopanib concentrations. The effect was not seen at the lower 20 mg daily dose.
How serious is the interaction between Istradefylline and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily if possible and monitor for pazopanib toxicity including liver tests.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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