Drug interactions
Istradefylline + Pimavanserin
Severity: Minor
Istradefylline and Pimavanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits CYP3A4 and may raise pimavanserin exposure. This could increase adverse effects including QT prolongation.
What this interaction means in plain words
Istradefylline and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Weak to moderate CYP3A4 inhibition by istradefylline at 40 mg/day reduces pimavanserin clearance.
What to do
Monitor for pimavanserin adverse effects when istradefylline 40 mg/day is used. Consider a pimavanserin dose reduction if tolerability issues arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Pimavanserin?
MediHelp rates the interaction as minor. Istradefylline and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits CYP3A4 and may raise pimavanserin exposure. This could increase adverse effects including QT prolongation.
How serious is the interaction between Istradefylline and Pimavanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pimavanserin adverse effects when istradefylline 40 mg/day is used. Consider a pimavanserin dose reduction if tolerability issues arise.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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