Drug interactions
Istradefylline + Praziquantel
Severity: Minor
Istradefylline and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, so praziquantel levels may increase. At 20 mg daily the effect is not expected to be significant.
What this interaction means in plain words
Istradefylline and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Praziquantel belongs to Anti Parasitic.
Why it happens
Istradefylline at higher doses weakly inhibits CYP3A4, reducing praziquantel metabolism.
What to do
Monitor for praziquantel adverse effects such as dizziness if istradefylline 40 mg daily is used. No action is needed at 20 mg daily.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Praziquantel?
MediHelp rates the interaction as minor. Istradefylline and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, so praziquantel levels may increase. At 20 mg daily the effect is not expected to be significant.
How serious is the interaction between Istradefylline and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel adverse effects such as dizziness if istradefylline 40 mg daily is used. No action is needed at 20 mg daily.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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