Drug interactions
Istradefylline + Quinine
Severity: Moderate
Istradefylline and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits CYP3A4 and P-gp, which may increase quinine exposure. Raised quinine levels increase the risk of cinchonism, hypoglycemia and QT prolongation.
What this interaction means in plain words
Istradefylline and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Istradefylline inhibits CYP3A4 and P-gp, decreasing quinine clearance and increasing absorption.
What to do
Monitor for quinine toxicity and consider an ECG, especially with istradefylline 40 mg/day. Reduce the quinine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Quinine?
MediHelp rates the interaction as moderate. Istradefylline and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses inhibits CYP3A4 and P-gp, which may increase quinine exposure. Raised quinine levels increase the risk of cinchonism, hypoglycemia and QT prolongation.
How serious is the interaction between Istradefylline and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity and consider an ECG, especially with istradefylline 40 mg/day. Reduce the quinine dose if adverse effects emerge.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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