Drug interactions
Istradefylline + Sorafenib
Severity: Minor
Istradefylline and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day weakly inhibits CYP3A4 and raised exposure of CYP3A4 substrates. Sorafenib exposure may rise modestly, though sorafenib is cleared by CYP3A4 and UGT1A9 and the effect is likely small.
What this interaction means in plain words
Istradefylline and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing sorafenib oxidative metabolism.
What to do
Monitor for sorafenib adverse effects such as hand-foot skin reaction, hypertension and diarrhea. Keep istradefylline at 20 mg/day where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Sorafenib?
MediHelp rates the interaction as minor. Istradefylline and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day weakly inhibits CYP3A4 and raised exposure of CYP3A4 substrates. Sorafenib exposure may rise modestly, though sorafenib is cleared by CYP3A4 and UGT1A9 and the effect is likely small.
How serious is the interaction between Istradefylline and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects such as hand-foot skin reaction, hypertension and diarrhea. Keep istradefylline at 20 mg/day where possible.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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