Drug interactions
Istradefylline + Topotecan
Severity: Moderate
Istradefylline and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses raises exposure to P-glycoprotein substrates. Topotecan is a P-gp substrate, so its levels and myelosuppressive toxicity could increase.
What this interaction means in plain words
Istradefylline and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Topotecan belongs to Oncology.
Why it happens
Istradefylline inhibits P-glycoprotein, decreasing topotecan efflux.
What to do
Monitor complete blood counts and consider lowering the topotecan dose if toxicity develops. Use the lowest effective istradefylline dose where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Topotecan?
MediHelp rates the interaction as moderate. Istradefylline and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses raises exposure to P-glycoprotein substrates. Topotecan is a P-gp substrate, so its levels and myelosuppressive toxicity could increase.
How serious is the interaction between Istradefylline and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and consider lowering the topotecan dose if toxicity develops. Use the lowest effective istradefylline dose where possible.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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