Drug interactions
Istradefylline + Vincristine
Severity: Moderate
Istradefylline and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates and may increase vincristine levels. This could worsen neurotoxicity and gastrointestinal toxicity, whereas 20 mg daily showed no such effect.
What this interaction means in plain words
Istradefylline and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Vincristine belongs to Oncology.
Why it happens
Dose-dependent inhibition of CYP3A4 and P-glycoprotein.
What to do
Monitor for neuropathy, constipation and cytopenias, particularly if istradefylline is given at 40 mg daily. Consider a vincristine dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Vincristine?
MediHelp rates the interaction as moderate. Istradefylline and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates and may increase vincristine levels. This could worsen neurotoxicity and gastrointestinal toxicity, whereas 20 mg daily showed no such effect.
How serious is the interaction between Istradefylline and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and cytopenias, particularly if istradefylline is given at 40 mg daily. Consider a vincristine dose reduction if toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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