Drug interactions
Istradefylline + Vinorelbine
Severity: Minor
Istradefylline and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline increases exposure to CYP3A4 substrates, which may raise vinorelbine levels. Increased myelosuppression and neurotoxicity are possible.
What this interaction means in plain words
Istradefylline and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Vinorelbine belongs to Oncology.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline.
What to do
Monitor blood counts and neuropathy, and prefer the lower istradefylline dose where clinically possible. Reduce the vinorelbine dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Vinorelbine?
MediHelp rates the interaction as minor. Istradefylline and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline increases exposure to CYP3A4 substrates, which may raise vinorelbine levels. Increased myelosuppression and neurotoxicity are possible.
How serious is the interaction between Istradefylline and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and prefer the lower istradefylline dose where clinically possible. Reduce the vinorelbine dose if toxicity occurs.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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