Drug interactions
Ivosidenib + Levonorgestrel
Severity: Moderate
Ivosidenib and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower systemic levonorgestrel exposure. Systemic and emergency levonorgestrel may be less effective, whereas an intrauterine system is less affected.
What this interaction means in plain words
Ivosidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Ivosidenib induces CYP3A4, increasing levonorgestrel clearance.
What to do
Prefer an intrauterine system or add a nonhormonal method during ivosidenib treatment. Avoid relying on oral levonorgestrel alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Levonorgestrel?
MediHelp rates the interaction as moderate. Ivosidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower systemic levonorgestrel exposure. Systemic and emergency levonorgestrel may be less effective, whereas an intrauterine system is less affected.
How serious is the interaction between Ivosidenib and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an intrauterine system or add a nonhormonal method during ivosidenib treatment. Avoid relying on oral levonorgestrel alone.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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