Drug interactions
Ivosidenib + Lidocaine
Severity: Minor
Ivosidenib and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and can lower exposure to CYP3A substrates. Lidocaine concentrations may fall, potentially reducing efficacy, for example in antiarrhythmic use. For local anesthesia the effect is of limited importance.
What this interaction means in plain words
Ivosidenib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Lidocaine belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP3A4, increasing lidocaine metabolism.
What to do
Monitor for reduced lidocaine effect when used systemically and titrate to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Lidocaine?
MediHelp rates the interaction as minor. Ivosidenib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP3A4 and can lower exposure to CYP3A substrates. Lidocaine concentrations may fall, potentially reducing efficacy, for example in antiarrhythmic use. For local anesthesia the effect is of limited importance.
How serious is the interaction between Ivosidenib and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced lidocaine effect when used systemically and titrate to response.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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