Drug interactions
Ivosidenib + Salbutamol
Severity: Moderate
Ivosidenib and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QT interval, and salbutamol may contribute additional risk through its cardiac effects and potassium-lowering action. This is of concern in patients with electrolyte imbalance or underlying heart disease.
What this interaction means in plain words
Ivosidenib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a possible contributor.
What to do
Monitor ECG and electrolytes, correcting potassium and magnesium. Reduce or interrupt ivosidenib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Salbutamol?
MediHelp rates the interaction as moderate. Ivosidenib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can prolong the QT interval, and salbutamol may contribute additional risk through its cardiac effects and potassium-lowering action. This is of concern in patients with electrolyte imbalance or underlying heart disease.
How serious is the interaction between Ivosidenib and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting potassium and magnesium. Reduce or interrupt ivosidenib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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