Drug interactions
Ivosidenib + Salmeterol
Severity: Moderate
Ivosidenib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer, so it may reduce salmeterol exposure and weaken bronchodilator effect. The clinical significance is uncertain because inhaled salmeterol has low systemic exposure, and the direction of effect differs from what is usually expected with an inhibitor. Ivosidenib also prolongs the QT interval, which adds a theoretical cardiac concern with the beta-agonist.
What this interaction means in plain words
Ivosidenib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Ivosidenib induces CYP3A4 and may lower salmeterol levels; additive QT effects are also possible.
What to do
Monitor asthma or COPD control and consider a rescue bronchodilator plan if efficacy declines. Obtain an ECG and check electrolytes if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ivosidenib and Salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Salmeterol?
MediHelp rates the interaction as moderate. Ivosidenib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer, so it may reduce salmeterol exposure and weaken bronchodilator effect. The clinical significance is uncertain because inhaled salmeterol has low systemic exposure, and the direction of effect differs from what is usually expected with an inhibitor. Ivosidenib also prolongs the QT interval, which adds a theoretical cardiac concern with the beta-agonist.
How serious is the interaction between Ivosidenib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and consider a rescue bronchodilator plan if efficacy declines. Obtain an ECG and check electrolytes if QT risk factors are present.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
