Drug interactions
Ivosidenib + Sorafenib
Severity: Major
Ivosidenib and Sorafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, which increases the risk of arrhythmia. Ivosidenib also induces CYP3A4 and may reduce sorafenib exposure, although CYP3A4 plays only a partial role in sorafenib clearance.
What this interaction means in plain words
Ivosidenib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation, plus CYP3A4 induction by ivosidenib.
What to do
Avoid the combination if possible. If used, monitor ECGs and electrolytes and assess sorafenib efficacy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sorafenib
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sorafenib?
MediHelp rates the interaction as major. Ivosidenib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, which increases the risk of arrhythmia. Ivosidenib also induces CYP3A4 and may reduce sorafenib exposure, although CYP3A4 plays only a partial role in sorafenib clearance.
How serious is the interaction between Ivosidenib and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor ECGs and electrolytes and assess sorafenib efficacy.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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