Drug interactions
Ivosidenib + Sunitinib
Severity: Major
Ivosidenib and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower sunitinib concentrations, potentially reducing antitumor efficacy. Both drugs also have QT-prolonging potential, so arrhythmia risk may rise.
What this interaction means in plain words
Ivosidenib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib lowers sunitinib exposure, with additive QT prolongation.
What to do
Avoid the combination if possible. If used together, monitor ECG and electrolytes and watch for loss of sunitinib efficacy, adjusting the dose as appropriate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sunitinib?
MediHelp rates the interaction as major. Ivosidenib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib induces CYP3A4 and may lower sunitinib concentrations, potentially reducing antitumor efficacy. Both drugs also have QT-prolonging potential, so arrhythmia risk may rise.
How serious is the interaction between Ivosidenib and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used together, monitor ECG and electrolytes and watch for loss of sunitinib efficacy, adjusting the dose as appropriate.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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