Drug interactions
Ivosidenib + Tolterodine
Severity: Moderate
Ivosidenib and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower tolterodine concentrations, but tolterodine's active metabolite and CYP2D6 route lessen the impact. Reduced bladder symptom control is possible. Ivosidenib also prolongs QT.
What this interaction means in plain words
Ivosidenib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
CYP3A4 induction by ivosidenib increases tolterodine clearance.
What to do
Monitor for reduced efficacy of tolterodine and adjust the dose or change agent if symptoms worsen. Monitor ECG given ivosidenib QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Tolterodine?
MediHelp rates the interaction as moderate. Ivosidenib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower tolterodine concentrations, but tolterodine's active metabolite and CYP2D6 route lessen the impact. Reduced bladder symptom control is possible. Ivosidenib also prolongs QT.
How serious is the interaction between Ivosidenib and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of tolterodine and adjust the dose or change agent if symptoms worsen. Monitor ECG given ivosidenib QT effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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