Drug interactions
Ivosidenib + Vinorelbine
Severity: Moderate
Ivosidenib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower vinorelbine concentrations, potentially reducing antitumor efficacy. The size of the effect on vinorelbine has not been well characterised.
What this interaction means in plain words
Ivosidenib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Induction of CYP3A4 by ivosidenib increases the metabolism of vinorelbine.
What to do
Consider alternatives to ivosidenib or vinorelbine if feasible. If both are used, monitor for reduced tumor response and for changes in toxicity when ivosidenib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Vinorelbine?
MediHelp rates the interaction as moderate. Ivosidenib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower vinorelbine concentrations, potentially reducing antitumor efficacy. The size of the effect on vinorelbine has not been well characterised.
How serious is the interaction between Ivosidenib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternatives to ivosidenib or vinorelbine if feasible. If both are used, monitor for reduced tumor response and for changes in toxicity when ivosidenib is started or stopped.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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