Drug interactions
Ixabepilone + Mifepristone
Severity: Major
Ixabepilone and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can raise ixabepilone exposure. Higher levels increase the risk of neutropenia, peripheral neuropathy and other toxicities of ixabepilone.
What this interaction means in plain words
Ixabepilone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ixabepilone by mifepristone.
What to do
Prefer an alternative to mifepristone during ixabepilone therapy. If unavoidable, monitor blood counts frequently between cycles and consider reducing the ixabepilone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ixabepilone with Mifepristone?
MediHelp rates the interaction as major. Ixabepilone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and can raise ixabepilone exposure. Higher levels increase the risk of neutropenia, peripheral neuropathy and other toxicities of ixabepilone.
How serious is the interaction between Ixabepilone and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to mifepristone during ixabepilone therapy. If unavoidable, monitor blood counts frequently between cycles and consider reducing the ixabepilone dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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