Drug interactions
Ixabepilone + Verapamil
Severity: Moderate
Ixabepilone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is metabolized by CYP3A4, so verapamil may increase its concentrations and raise the risk of neuropathy, neutropenia and other toxicities.
What this interaction means in plain words
Ixabepilone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of ixabepilone.
What to do
Prefer a non-CYP3A4-inhibiting alternative to verapamil where possible. If combined, monitor blood counts and neuropathy closely and consider ixabepilone dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Ixabepilone with Verapamil?
MediHelp rates the interaction as moderate. Ixabepilone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is metabolized by CYP3A4, so verapamil may increase its concentrations and raise the risk of neuropathy, neutropenia and other toxicities.
How serious is the interaction between Ixabepilone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting alternative to verapamil where possible. If combined, monitor blood counts and neuropathy closely and consider ixabepilone dose reduction.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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