Drug interactions
Ixabepilone + Zafirlukast
Severity: Moderate
Ixabepilone and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is a CYP3A4 substrate with considerable toxicity such as neuropathy and myelosuppression. Zafirlukast is a weak inhibitor so the effect is likely small, but exposure increases could be important.
What this interaction means in plain words
Ixabepilone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by zafirlukast reduces ixabepilone clearance.
What to do
Monitor blood counts and for peripheral neuropathy more closely; consider an alternative to zafirlukast such as montelukast if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Ixabepilone with Zafirlukast?
MediHelp rates the interaction as moderate. Ixabepilone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is a CYP3A4 substrate with considerable toxicity such as neuropathy and myelosuppression. Zafirlukast is a weak inhibitor so the effect is likely small, but exposure increases could be important.
How serious is the interaction between Ixabepilone and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for peripheral neuropathy more closely; consider an alternative to zafirlukast such as montelukast if feasible.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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