Drug interactions
Kanamycin + Warfarin
Severity: Moderate
Kanamycin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic aminoglycoside antibiotics may increase the INR in patients taking warfarin. Reduced vitamin K from gut flora and illness-related factors may contribute, which may lead to bleeding.
What this interaction means in plain words
Kanamycin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction of vitamin K-producing gut flora and reduced vitamin K availability; the mechanism is not firmly established.
What to do
Monitor INR during and after kanamycin therapy and reduce the warfarin dose if the INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Kanamycin with Warfarin?
MediHelp rates the interaction as moderate. Kanamycin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic aminoglycoside antibiotics may increase the INR in patients taking warfarin. Reduced vitamin K from gut flora and illness-related factors may contribute, which may lead to bleeding.
How serious is the interaction between Kanamycin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR during and after kanamycin therapy and reduce the warfarin dose if the INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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