Drug interactions
Kava + Secobarbital
Severity: Moderate
Kava and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kava has sedative-anxiolytic effects and can add to secobarbital's CNS depression. Kava is also associated with hepatotoxicity, adding concern.
What this interaction means in plain words
Kava and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABAergic CNS depression from kavalactones.
What to do
Avoid kava while taking secobarbital. Monitor for excess sedation and liver injury if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Kava with Secobarbital?
MediHelp rates the interaction as moderate. Kava and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kava has sedative-anxiolytic effects and can add to secobarbital's CNS depression. Kava is also associated with hepatotoxicity, adding concern.
How serious is the interaction between Kava and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid kava while taking secobarbital. Monitor for excess sedation and liver injury if used.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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