Drug interactions
Ketamine + Lenacapavir
Severity: Moderate
Ketamine and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise ketamine exposure, with the effect persisting for months after subcutaneous dosing. This may enhance sedation and psychotomimetic effects.
What this interaction means in plain words
Ketamine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by lenacapavir reduces ketamine metabolism.
What to do
Titrate ketamine cautiously and monitor sedation and hemodynamics. Consider a reduced ketamine dose, particularly with oral use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Ketamine with Lenacapavir?
MediHelp rates the interaction as moderate. Ketamine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise ketamine exposure, with the effect persisting for months after subcutaneous dosing. This may enhance sedation and psychotomimetic effects.
How serious is the interaction between Ketamine and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine cautiously and monitor sedation and hemodynamics. Consider a reduced ketamine dose, particularly with oral use.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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