Drug interactions
Ketamine + Levetiracetam
Severity: Moderate
Ketamine and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, dizziness and psychomotor impairment, and combined use may deepen these effects. Levetiracetam may also affect behavioral symptoms, which could overlap with ketamine's psychotomimetic effects.
What this interaction means in plain words
Ketamine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation level and mental status during and after ketamine administration, and do not interrupt levetiracetam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Levetiracetam?
MediHelp rates the interaction as moderate. Ketamine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, dizziness and psychomotor impairment, and combined use may deepen these effects. Levetiracetam may also affect behavioral symptoms, which could overlap with ketamine's psychotomimetic effects.
How serious is the interaction between Ketamine and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and mental status during and after ketamine administration, and do not interrupt levetiracetam.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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