Drug interactions
Ketamine + Maprotiline
Severity: Moderate
Ketamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine produces dissociation and sedation, and maprotiline adds sedative effects, so combined use can increase CNS depression. Ketamine can also raise blood pressure and heart rate, while maprotiline can cause cardiovascular effects, and maprotiline lowers the seizure threshold.
What this interaction means in plain words
Ketamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and overlapping cardiovascular effects.
What to do
Monitor sedation level, blood pressure and heart rate when ketamine is given, and tell the anesthesia team about maprotiline. Use the lowest effective ketamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Maprotiline?
MediHelp rates the interaction as moderate. Ketamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine produces dissociation and sedation, and maprotiline adds sedative effects, so combined use can increase CNS depression. Ketamine can also raise blood pressure and heart rate, while maprotiline can cause cardiovascular effects, and maprotiline lowers the seizure threshold.
How serious is the interaction between Ketamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, blood pressure and heart rate when ketamine is given, and tell the anesthesia team about maprotiline. Use the lowest effective ketamine dose.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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