Drug interactions
Ketamine + Memantine-donepezil
Severity: Moderate
Ketamine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine and ketamine are both NMDA receptor antagonists, so combined use may increase CNS effects such as hallucinations, agitation, dizziness and confusion. The combination is not an absolute contraindication.
What this interaction means in plain words
Ketamine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive NMDA receptor antagonism.
What to do
Monitor for psychotomimetic and sedative effects and reduce the ketamine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Ketamine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Memantine and ketamine are both NMDA receptor antagonists, so combined use may increase CNS effects such as hallucinations, agitation, dizziness and confusion. The combination is not an absolute contraindication.
How serious is the interaction between Ketamine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for psychotomimetic and sedative effects and reduce the ketamine dose if needed.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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