Drug interactions
Ketamine + Metaxalone
Severity: Moderate
Ketamine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine produces dissociation and sedation, and metaxalone may add to central nervous system depression. The risk of excessive sedation, impaired coordination and, at anaesthetic doses, impaired airway reflexes may be increased.
What this interaction means in plain words
Ketamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor level of consciousness and respiratory status when ketamine is given to patients taking metaxalone. Reduce the dose of either agent if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Metaxalone?
MediHelp rates the interaction as moderate. Ketamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine produces dissociation and sedation, and metaxalone may add to central nervous system depression. The risk of excessive sedation, impaired coordination and, at anaesthetic doses, impaired airway reflexes may be increased.
How serious is the interaction between Ketamine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status when ketamine is given to patients taking metaxalone. Reduce the dose of either agent if oversedation occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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