Drug interactions
Ketamine + Nadolol
Severity: Moderate
Ketamine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may blunt ketamine's sympathomimetic effects on heart rate and blood pressure. In catecholamine-depleted or compromised patients, ketamine can act as a direct myocardial depressant, so hypotension and bradycardia may occur.
What this interaction means in plain words
Ketamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Beta-blockade opposes ketamine's indirect sympathomimetic effect, unmasking its direct myocardial depression.
What to do
Monitor blood pressure and heart rate closely and titrate ketamine slowly; have vasopressors available. Do not stop chronic beta-blocker therapy abruptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Ketamine with Nadolol?
MediHelp rates the interaction as moderate. Ketamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may blunt ketamine's sympathomimetic effects on heart rate and blood pressure. In catecholamine-depleted or compromised patients, ketamine can act as a direct myocardial depressant, so hypotension and bradycardia may occur.
How serious is the interaction between Ketamine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and titrate ketamine slowly; have vasopressors available. Do not stop chronic beta-blocker therapy abruptly.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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