Drug interactions
Ketamine + Nebivolol
Severity: Moderate
Ketamine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine usually stimulates the sympathetic system, but in patients on beta-blockers or with depleted catecholamines it may cause myocardial depression and hypotension. Nebivolol reduces the compensatory sympathetic response to anesthesia.
What this interaction means in plain words
Ketamine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression; beta-blockade blunts ketamine's sympathomimetic effects.
What to do
Monitor blood pressure and heart rate continuously during anesthesia. Be ready to treat hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Nebivolol?
MediHelp rates the interaction as moderate. Ketamine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine usually stimulates the sympathetic system, but in patients on beta-blockers or with depleted catecholamines it may cause myocardial depression and hypotension. Nebivolol reduces the compensatory sympathetic response to anesthesia.
How serious is the interaction between Ketamine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during anesthesia. Be ready to treat hypotension with fluids or vasopressors.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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